SOTIO Presents Positive Results from Non-Human Primate Study of SOT106, a Potential Best-in-Class ADC for Treatment of Sarcoma
- Preclinical studies indicate that SOT106 (anti-LRRC15 ADC) is highly effective and well-tolerated with significant promise for treating sarcomas and potentially other LRRC15-positive malignancies;
- IND filing anticipated in Q4 2026;
- Program advancing towards clinical readiness and exploring partnering opportunities.
SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, today announced favorable preclinical results supporting the development of SOT106, its antibody-drug conjugate for the treatment of sarcoma, at the Connective Tissue Oncology Society (CTOS) Annual Meeting taking place November 12-15, 2025, in Boca Raton, FL.
SOTIO to Present Data Highlighting Progress Across ADC and Immunocytokine Programs at Upcoming Scientific Conferences
SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, today announced it will present new preclinical and translational data from multiple investigational programs at two scientific conferences in November – the World ADC Conference in San Diego, California, and PEGS Europe, in Lisbon, Portugal.
SOTIO Reports Promising Preclinical Data on Antibody-Drug Conjugates SOT109 and SOT106, Underscoring Best-in-Class Potential for Solid Tumor Treatments
• SOT109 (targeting cadherin-17) exhibits potent efficacy and a favorable safety profile in preclinical models of colorectal cancer; currently in IND-enabling stage with IND filing anticipated in 2026;
• SOT106 (targeting LRRC15) exhibits robust preclinical efficacy in mesenchymal tumors, including broad subset of sarcomas.
SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, this week presented preclinical data on two of its leading antibody-drug conjugate (ADC) candidates, SOT109 and SOT106, at the American Association for Cancer Research (AACR) Annual Meeting in Chicago, IL.
SOTIO Biotech B.V.
Zuidplein 168
1077 XV Amsterdam
Netherlands
Zuidplein 168
1077 XV Amsterdam
Netherlands
SOTIO Biotech a.s.
Českomoravská 2532/19b
190 00 Prague 9
Czech Republic
Českomoravská 2532/19b
190 00 Prague 9
Czech Republic
SOTIO Biotech AG
Lichtstrasse 35 - WSJ-210
4056 Basel
Switzerland
Lichtstrasse 35 - WSJ-210
4056 Basel
Switzerland
SOTIO Biotech Inc.
180 Canal St., Suite 300
Boston, MA 02114
USA
180 Canal St., Suite 300
Boston, MA 02114
USA
