Scientist – ADC Discovery Team

At SOTIO Biotech, part of the PPF investment group, we are shaping the future of immunotherapy for cancer patients. It's more than a job. It's a mission with great impact and meaningful goals. 

⏩ We now have a unique career opportunity for an enthusiastic scientist who is eager to push boundaries and explore novel approaches. You can contribute to advancing innovative methods of cancer treatment and translating scientific knowledge into cancer therapeutics ⏪

What is our goal?

Our Antibody-Drug Conjugate (ADC) Discovery team, part of Research and Early Development division, lays the foundation for successful ADC therapies by addressing key scientific and strategic challenges at the outset of the drug development process. In the initial phase we support identification of an optimal target or target pair, prioritization of promising hits, their experimental characterization and validation using scientific literature research, public preclinical data review and in-house in vitro functional assays. Once a preclinical project is launched, we evaluate and optimize antibody properties, ADC efficacy and mechanism of action, providing essential data for clinical candidate selection and regulatory submissions.

What working in the ADC Discovery team at Sotio Biotech brings to you?

📌 Purposeful work that can ultimately contribute to improving the lives of cancer patients 

📌 Meaningful work with a direct practical real-world application

📌 Impactful role that can shape Sotio’s preclinical pipeline

📌 Opportunity to learn from experts on various aspects of drug development

📌 Diverse hands-on work using cutting-edge laboratory equipment

📌 Becoming part of a team where we treasure cooperation and open communication

📌 Opportunities for personal and professional growth

Your Activities 🔬

• Comprehensively review relevant scientific literature and other available resources to advance ADC target scouting, hit prioritization and transit promising hits into preclinical projects 

• Integrate and interpret collected data, prepare summary presentations and analyses and clearly communicate conclusions in internal meetings

• Connect the data to actionable recommendations to enable informed decision-making

• Develop strategy for in vitro experimental validation of prioritized hits

• Design, execute and troubleshoot cell-based in vitro assays; maintain accurate and detailed records of experiments

• Compile, organize, and present experimental data, prepare scientific reports and communicate findings in internal meetings

• Develop preclinical cell models using gene transfer techniques to predict ADC efficacy and safety profiles

• Serve as a project representative providing expert input in a cross-functional team setting

• Work both independently and as part of a collaborative team to achieve shared goals

Qualification requirements

✅ Ph.D. in cancer biology/cell biology/immunology/molecular biology/pharmacology or related fields

✅ Strong ability to analyze and interpret scientific data, integrate data from multiple resources, with experience in conducting complex literature reviews

✅ Strong ability to draw clear conclusions and link findings to recommendations

✅ Attention to detail in a rapidly changing environment and ability to work on multiple programs simultaneously

✅ Independence, proactiveness, and self-organization

✅ Good communication and leadership skills to drive projects forward

✅ Hands-on experience in cell culture handling, cell-based assays, and molecular biology techniques such as proliferation assessment, flow cytometry, ELISA, Western blotting, RT-qPCR, fluorescence microscopy

✅ Ability to conduct data analysis using GraphPad PRISM or equivalent software

✅ Knowledge of the English language on the advanced level is required (written and verbal communication skills)

✅ Flexibility to acquire additional competencies and skillsets as needed

✅ Experience with oncology projects and/or drug development is an advantage

✅ Working with hazardous biological and chemical substances under the appropriate safety measures is part of the job description

✅ Hepatitis B vaccination will be required

📌 Where is our office

• Českomoravská 2532/19b, Libeň, 190 00 Praha 9, Česká republika
   

Are you ready to take on this challenge and become part of our scientific team? 

The selection process usually involves 2-3 rounds, during which we get to know each other and clarify our expectations. 

We look forward to meeting you! 

SOTIO Biotech team