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The design of SOT101 (formerly SO-C101) enables its fusion to monoclonal antibodies, allowing it to precisely target tumor antigens, tumor stroma or T cells. As a result, SOTIO is developing SOT201 (formerly SO-C108), an immunocytokine fusing SOT101 to pembrolizumab in order to directly target T cells. This fusion allows for spatial colocalization of an IL-15 superagonist with an anti-PD-1 checkpoint inhibitor, to best enhance their synergistic modes of action and potentially improve outcomes. SO-C108 is one of the first IL-15/PD-1 targeting immunocytokines.
Preclinical data indicate that SOT201 (formerly SO-C108) administration is more efficacious than the administration of SOT101 (formerly SO-C101) and pembrolizumab in combination.