Publications

Lenka Kasikova, Jana Rakova, Michal Hensler, Tereza Lanickova, Jana Tomankova, Josef Pasulka, Jana Drozenova, Katerina Mojzisova , Anna Fialova, Sarka Vosahlikova, Jan Laco, Ales Ryska, Pavel Dundr, Roman Kocian, Tomas Brtnicky, Petr Skapa, Linda Capkova, Marek Kovar, Jan Prochazka, Ivan Praznovec, Vladimir Koblizek, Alice Taskova, Hisashi Tanaka, Robert Lischke, Fernando Casas Mendez, Jiri Vachtenheim Jr , Viola Heinzelmann-Schwarz, Francis Jacob, Iain A McNeish, Michal J Halaska, Lukas Rob, David Cibula, Sandra Orsulic, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer

Peter Holicek, Emma Guilbaud, Vanessa Klapp, Iva Truxova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova

Type I interferon and cancer

Jenny Sprooten, Raquel S Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M Borras, Lisa Kinget, Jitka Fucíková, Radek Spisek, Lenka Palova Jelinkova, Oliver Kepp, Guido Kroemer, Dmitri V Krysko, An Coosemans, Rianne D W Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M Clement, Peter Vandenabeele , Laurence Zitvogel, Abhishek D Garg

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Peter Holicek, Iva Truxova , Jana Rakova , Cyril Salek, Michal Hensler, Marek Kovar, Milan Reinis, Romana Mikyskova, Josef Pasulka, Sarka Vosahlikova, Hana Remesova, Iva Valentova, Daniel Lysak, Monika Holubova , Petr Kaspar, Jan Prochazka, Lenka Kasikova, Radek Spisek, Lorenzo Galluzzi, Jitka Fucikova

Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients

Iva Truxova, David Cibula, Radek Spisek, Jitka Fucikova

Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma

Zuzana Antosova, Nada Podzimkova, Jakub Tomala, Katerina Augustynkova, Katerina Sajnerova, Eva Nedvedova, Milada Sirova, Guy de Martynoff, David Bechard, Ulrich Moebius, Marek Kovar, Radek Spisek , Irena Adkins.

SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity

Michal Hensler, Jana Rakova, Lenka Kasikova, Tereza Lanickova, Josef Pasulka, Peter Holicek, Marek Hraska, Tereza Hrnciarova, Pavla Kadlecova, Andreu Schoenenberger, Klara Sochorova, Daniela Rozkova, Ludek Sojka, Jana Drozenova, Jan Laco, Rudolf Horvath, Michal Podrazil, Guo Hongyan, Tomas Brtnicky, Michal J Halaska, Lukas Rob, Ales Ryska, An Coosemans, Ignace Vergote, Abhishek D Garg, David Cibula, Jirina Bartunkova, Radek Spisek, Jitka Fucikova.

Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines

Jitka Fucikova, Michal Hensler, Lenka Kasikova, Tereza Lanickova, Josef Pasulka, Jana Rakova, Jana Drozenova, Tessa Fredriksen, Marek Hraska, Tereza Hrnciarova, Klara Sochorova, Daniela Rozkova, Ludek Sojka, Pavel Dundr, Jan Laco, Tomas Brtnicky, Ivan Praznovec, Michael J Halaska, Lukas Rob, Ales Ryska, An Coosemans, Ignace Vergote, David Cibula, Jirina Bartunkova, Jérôme Galon, Lorenzo Galluzzi, Radek Spisek

An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors

Raquel S Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N Berneman, Benoit Beuselinck, Kalijn F Bol, Jannie Borst, An Coosemans, Angeliki Datsi, Jitka Fučíková, Lisa Kinget, Bart Neyns, Gerty Schreibelt, Evelien Smits, Rüdiger V Sorg, Radek Spisek, Kris Thielemans, Sandra Tuyaerts, Steven De Vleeschouwer, I Jolanda M de Vries, Yanling Xiao, Abhishek D Garg

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

Nicholas J Vogelzang, Tomasz M Beer, Winald Gerritsen, Stéphane Oudard, Pawel Wiechno, Bozena Kukielka-Budny, Vladimir Samal , Jaroslav Hajek, Susan Feyerabend, Vincent Khoo, Arnulf Stenzl, Tibor Csöszi, Zoran Filipovic, Frederico Goncalves, Alexander Prokhorov, Eric Cheung , Arif Hussain, Nuno Sousa, Amit Bahl, Syed Hussain, Harald Fricke, Pavla Kadlecova, Tomas Scheiner, Roman P Korolkiewicz, Jirina Bartunkova, Radek Spisek; VIABLE Investigators

Efficacy and Safety of Autologous Dendritic Cell-Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer: The VIABLE Phase 3 Randomized Clinical Trial

Jitka Fucikova, Lenka Palova-Jelinkova, Vanessa Klapp, Peter Holicek, Tereza Lanickova, Lenka Kasikova, Jana Drozenova, David Cibula, Beatriz Álvarez-Abril, Elena García-Martínez, Radek Spisek, Lorenzo Galluzzi.

Immunological control of ovarian carcinoma by chemotherapy and targeted anticancer agents

Nicholas J Vogelzang, Tomasz M Beer, Winald Gerritsen, Stéphane Oudard, Pawel Wiechno, Bozena Kukielka-Budny, Vladimir Samal, Jaroslav Hajek, Susan Feyerabend, Vincent Khoo, Arnulf Stenzl, Tibor Csöszi, Zoran Filipovic, Frederico Goncalves, Alexander Prokhorov, Eric Cheung , Arif Hussain, Nuno Sousa, Amit Bahl, Syed Hussain, Harald Fricke, Pavla Kadlecova, Tomas Scheiner, Roman P Korolkiewicz, Jirina Bartunkova, Radek Spisek, VIABLE Investigators.

Efficacy and Safety of Autologous Dendritic Cell-Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer: The VIABLE Phase 3 Randomized Clinical Trial

Lukas Rob, David Cibula, Pawel Knapp, Peter Mallmann, Jaroslav Klat, Lubos Minar, Pavel Bartos, Josef Chovanec, Petr Valha, Marek Pluta, Zdenek Novotny, Jiri Spacek, Bohuslav Melichar, Dariusz Kieszko, Jitka Fucikova, Tereza Hrnciarova, Roman Pawel Korolkiewicz, Marek Hraska, Jirina Bartunkova, Radek Spisek.

Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial

Jitka Fucikova, An Coosemans, Sandra Orsulic, David Cibula, Ignace Vergote, Lorenzo Galluzzi, Radek Spisek.

Immunological configuration of ovarian carcinoma: features and impact on disease outcome

David Cibula, Lukas Rob, Peter Mallmann, Pawel Knapp, Jaroslav Klat, Josef Chovanec, Lubos Minar, Bohuslav Melichar, Alexander Hein, Dariusz Kieszko, Marek Pluta, Jiri Spacek, Pavel Bartos, Pauline Wimberger, Radoslaw Madry, Janina Markowska, Joanna Streb, Petr Valha, Hariz Iskandar Bin Hassan, Ladislav Pecen, Lorenzo Galluzzi, Jitka Fucikova, Tereza Hrnciarova, Marek Hraska, Jirina Bartunkova, Radek Spisek.

Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial

Milada Zemanova, Marketa Cernovska, Libor Havel, Tomas Bartek, Sarka Lukesova, Jitka Jakesova, Jaroslav Vanasek, Pavel Reiterer, Juraj Kultan, Igor Andrasina, Lenka Siskova, Leona Koubkova, Jana Skrickova, Frantisek Salajka, Milos Pesek, Petr Klepetko, Juraj Beniak, Harald Fricke, Pavla Kadlecova, Roman P Korolkiewicz, Marek Hraska, Jirina Bartunkova, Radek Spisek .

Autologous dendritic cell-based immunotherapy (DCVAC/LuCa) and carboplatin/paclitaxel in advanced non-small cell lung cancer: A randomized, open-label, phase I/II trial

Ladislav Sivák, Vladimír Šubr, Jiřina Kovářová, Barbora Dvořáková, Milada Šírová, Blanka Říhová, Eva Randárová, Michal Kraus, Jakub Tomala, Martin Studenovský, Michaela Vondráčková, Radislav Sedláček, Petr Makovický, Jitka Fučíková, Šárka Vošáhlíková, Radek Špíšek, Libor Kostka, Tomáš Etrych, Marek Kovář.

Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

Jana Rakova , Iva Truxova , Peter Holicek , Cyril Salek , Michal Hensler , Lenka Kasikova , Josef Pasulka , Monika Holubova, Marek Kovar , Daniel Lysak , Justin P Kline , Zdenek Racil , Lorenzo Galluzzi , Radek Spisek , Jitka Fucikova

TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients

Vladimír Koucký, Kamila Hladíková, Eliška Táborská, Jan Bouček, Marek Grega, Radek Špíšek, Anna Fialová.

The cytokine milieu compromises functional capacity of tumor-infiltrating plasmacytoid dendritic cells in HPV-negative but not in HPV-positive HNSCC

Jitka Fucikova, Radek Spisek, Guido Kroemer, Lorenzo Galluzzi.

Calreticulin and cancer

Anna Grohová, Klára Dáňová, Irena Adkins, Zdeněk Šumník, Lenka Petruželková, Barbora Obermannová, Stanislava Koloušková, Radek Špíšek, Lenka Palová-Jelínková.

Myeloid - derived suppressor cells in Type 1 diabetes are an expanded population exhibiting diverse T-cell suppressor mechanisms

Iva Truxova, Lenka Kasikova, Cyril Salek, Michal Hensler, Daniel Lysak, Peter Holicek, Pavla Bilkova, Monika Holubova, Xiufen Chen, Romana Mikyskova, Milan Reinis , Marek Kovar, Barbora Tomalova, Justin P Kline, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients

Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato , Fernando Aranda, Sylvère Durand, Alexandre Boissonnas, Jitka Fucikova, Laura Senovilla, David Enot, Michal Hensler, Margerie Kremer, Gautier Stoll, Yang Hu, Chiara Massa, Silvia C Formenti, Barbara Seliger, Olivier Elemento, Radek Spisek, Fabrice André, Laurence Zitvogel, Suzette Delaloge, Guido Kroemer, Lorenzo Galluzzi

Publisher Correction: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Anna Fialová, Vladimír Koucký, Martina Hajdušková, Kamila Hladíková, Radek Špíšek

Immunological Network in Head and Neck Squamous Cell Carcinoma-A Prognostic Tool Beyond HPV Status

Michal Hensler, Lenka Kasikova, Karel Fiser, Jana Rakova, Petr Skapa, Jan Laco, Tereza Lanickova, Ladislav Pecen, Iva Truxova, Sarka Vosahlikova, Irena Moserova, Ivan Praznovec, Vit Drochytek, Martina Rehackova, Tomas Brtnicky, Lukas Rob, Vladimir Benes, Jelena Pistolic, Ludek Sojka, Ales Ryska, Catherine Sautes-Fridman, Wolf Herve Fridman, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova

M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer

Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato, Fernando Aranda, Sylvère Durand, Alexandre Boissonnas , Jitka Fucikova, Laura Senovilla, David Enot, Michal Hensler, Margerie Kremer, Gautier Stoll, Yang Hu, Chiara Massa, Silvia C Formenti, Barbara Seliger, Olivier Elemento, Radek Spisek, Fabrice André, Laurence Zitvogel, Suzette Delaloge, Guido Kroemer, Lorenzo Galluzzi.

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Jitka Fucikova, Radek Spisek, Guido Kroemer, Lorenzo Galluzzi

Calreticulin and cancer

L.Galluzzi, I. Vitale, S. Warren, S. Adjemian, P. Agostinis, A.B. Martinez, T. A Chan, G.Coukos, S. Demaria, E. Deutsch, D. Draganov, R. L Edelson, Silvia C Formenti, J. Fucikova, L. Gabriele, U. S. Gaipl, S. R. Gameiro, A. D. Garg, E. Golden, J. Han , K. J. Harrington, A. Hemminki, J. W. Hodge, D. M. S. Hossain, T. Illidge, M. Karin , H. L Kaufman, O. Kepp, G. Kroemer, J. J. Lasarte, S. Loi, M. T. Lotze, G. Manic, T. Merghoub, A. A. Melcher, K. L Mossman, F. Prosper, Ø. Rekdal, M. Rescigno, C. Riganti, A. Sistigu, M. J Smyth, R. Spisek, J. Stagg , B. E Strauss, D. Tang, K. Tatsuno, S. W. van Gool, P. Vandenabeele, T. Yamazaki, D. Zamarin, L. Zitvogel, A. Cesano, F. M. Marincola.

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

O. Palata, N. Podzimkova Hradilova, D. Mysiková, B. Kutna, H. Mrazkova, R. Lischke, R. Spisek, I. Adkins.

Detection of tumor antigens and tumor-antigen specific T cells in NSCLC patients: Correlation of the quality of T cell responses with NSCLC subtype.

I. Vanmeerbeek, J. Sprooten, D. De Ruysscher, S. Tejpar, P. Vandenberghe, J. Fucikova, R. Spisek, L. Zitvogel, G. Kroemer, L. Galluzzi, A.D. Garg.

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology.

L. Kasikova, M. Hensler, I. Truxova, P. Skapa, J. Laco, L. Belicova, I. Praznovec, S. Vosahlikova, M.J.Halaska, T. Brtnicky, L. Rob, J. Presl, J. Kostun, I. Cremer, A. Ryska, G. Kroemer, L. Galluzzi, R. Spisek, J.Fucikova.

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients.

J. Fucikova, L.Palova-Jelinkova, J. Bartunkova, R. Spisek

Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications.

K. Hladíková, V. Koucký, J. Bouček, J. Laco, M. Grega, M. Hodek, M. Zábrodský, M. Vošmik, K. Rozkošová, H. Vošmiková, P. Čelakovský, V. Chrobok, A. Ryška, R. Špíšek, A. Fialová

Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells.

J. Fucikova, J.P. Kline, L. Galluzzi, R. Spisek.

Calreticulin arms NK cells against leukemia.

I. Truxova, L. Kasikova, C. Salek, M. Hensler, D. Lysak, P. Holicek, P. Bilkova, M. Holubova, X. Chen, R. Mikyskova, M. Reinis, M. Kovar, B. Tomalova, J.P. Kline, L. Galluzzi, R. Spisek, J. Fucikova

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients.

L. Kasikova, I. Truxova, I. Cremer, C. Sautes-Fridman, O. Kepp, G. Kroemer, R. Spisek, J. Fucikova.

Side-by-side comparison of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death.

A.M. Chalupova, S. Vosahlikova, D. Rozkova, K. Sochorova, L. Palova-Jelinkova, J. Bartunkova, R. Spisek, J. Fucikova.

Methods to assess DC-dependent priming of T cell responses by dying cells.

P. Holicek, I. Truxova, L. Kasikova, S. Vosahlikova, C.Salek, J. Rakova, M. Holubova, D. Lysak, I. Cremer, R. Spisek, J. Fucikova.

Assessment of NK cell-mediated cytotoxicity by flow cytometry after rapid, high-yield isolation from peripheral blood.

O. Palata, N. Hradilova Podzimkova, E. Nedvedova, A. Umprecht, L. Sadilkova, L. Palova Jelinkova, R. Spisek, I. Adkins

Radiotherapy in Combination With Cytokine Treatment.

D. P. Funda, L. Palová-Jelínková, J. Goliáš, Z. Kroulíková, A. Fajstová, T. Hudcovic, R. Špíšek

Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

J. Fucikova, J. Rakova, M. Hensler, L. Kasikova, L. Belicová, K. Hladikova, I. Truxova, P. Skapa, J. Laco, L. Pecen, I. Praznovec, M.J.Halaska, T. Brtnicky, R. Kodet, A. Fialová, J. Pineau, A. Gey, E. Tartour, A. Ryska, L. Galluzzi, R. Spisek.

TIM-3 Dictates Functional Orientation of the Immune Infiltrate in Ovarian Cancer.

A. Grohová, K. Dáňová, R. Špíšek, L. Palová-Jelínková

Cell Based Therapy for Type 1 Diabetes: Should We Take Hyperglycemia Into Account?

I. Truxova, L. Kasikova, M. Hensler, P. Skapa, J. Laco, L. Pecen, L. Belicova, I. Praznovec, M.J. Halaska, T. Brtnicky, E. Salkova, L. Rob, R. Kodet, J. Goc, C. Sautes-Fridman, W.H. Fridman, A. Ryska, L.Galluzzi, R. Spisek, J. Fucikova

Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.

T. Buchler, P. Vasek, R. Spisek, P. Skrobanek, V. Horejsi

Tumour devascularisation as a potential immunotherapeutic strategy.

M. Smith, E. García-Martínez, M.R. Pitter, J. Fucikova, R. Spisek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Toll-like receptor agonists in cancer immunotherapy.

V. Čermák, A. Gandalovičová, L. Merta, J. Fučíková, R. Špíšek, D. Rösel, J. Brábek

RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment.

L. Bezu, O. Kepp, G. Cerrato, J. Pol, J. Fucikova, R. Spisek, L.Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Peptide-based vaccines in anticancer therapy.

J.G. Pol, S. Lévesque, S. Workenhe, S. Gujar, F. Le Boeuf, D.R.Clements, J.E. Fahrner, L. Fend, J.C. Bell, K.L. Mossman, J. Fucikova, R. Spisek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.

K. Hladíková, S. Partlová, V. Koucký, J. Bouček, J.F. Fonteneau, M. Zábrodský, R. Tachezy, M. Grega, R. Špíšek, A. Fialová

Dysfunction of HPV16-specific CD8+ T cells derived from oropharyngeal tumors is related to the expression of Tim-3 but not PD-1.

D.P. Funda, J. Goliáš, T. Hudcovic, H. Kozáková, R. Špíšek, L. Palová-Jelínková

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

E. García-Martínez, M. Smith, A. Buqué, F.Aranda, F.A. de la Peña, A. Ivars, M.S. Cánovas, M. A. V. Conesa, J. Fucikova, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

I. Adkins, N. Hradilova, O. Palata, L. Sadilkova, L. Palova-Jelinkova, R. Spisek

High hydrostatic pressure in cancer immunotherapy and biomedicine.

J. Fucikova , L. Kasikova, I. Truxova, J. Laco, P. Skapa , A. Ryska, R. Spisek

Relevance of the chaperone-like protein calreticulin for the biological behavior and clinical outcome of cancer

J. Fučíková, M. Podrazil, L. Jarolim, P. Bilková, M. Hensler, E. Becht, Z. Gasová, J. Kloucková, J. Kayserová, R. Horváth, A. Fialová, K. Vávrová, K. Sochorová, D. Rožková, R. Špíšek, J. Bartůňková

Phase I/II trial of dendritic cell-based active cellular immunotherapy with DCVAC/PCa in patients with rising PSA after primary prostatectomy or salvage radiotherapy for the treatment of prostate cancer.

C. Vanpouille-Box, C. Lhuillier, L. Bezu, F. Aranda, T. Yamazaki, O. Kepp, J. Fucikova, R. Spisek, S. Demaria, S.C. Formenti, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Immune checkpoint blockers for cancer therapy.

R. Mikyskova, M. Indrova, I. Stepanek, I. Kanchev, J. Bieblova, S. Vosahlikova, I. Moserova, I. Truxova, J. Fucikova, J. Bartunkova, R. Spisek, R. Sedlacek, M. Reinis

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure inhibit prostate tumor growth in TRAMP mice

L. Urbanová, N. Hradilová, I. Moserová, Š. Vošahliková, L. Sadílková, M. Henslera, R. Špíšek, I. Adkins

High hydrostatic pressure affects antigenic pool in tumor cells: Implication for dendritic cell-based cancer immunotherapy.

I. Adkins, L. Sadílková, N. Hradilová, J. Tomala, M. Kovář & R. Špíšek

Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells.

N. Hradilová, L. Sadilková, O. Palata, D. Mysikova, H. Mrázková, R. Lischke, R. Špíšek, I. Adkins

Generation of dendritic cell-based vaccine using high hydrostatic pressure for non-small cell lung cancer immunotherapy.

K. Dáňová, A. Grohová, P. Strnadová, D.P. Funda, Z. Šumník, J. Lebl, O. Cinek, Š. Průhová, S. Koloušková, B. Obermannová, L. Petruželková, A. Šedivá, P. Fundová, K. Buschard, R. Špíšek, L. Palová-Jelínková.

Tolerogenic Dendritic Cells from Poorly Compensated Type 1 Diabetes Patients Have Decreased Ability To Induce Stable Antigen-Specific T Cell Hyporesponsiveness and Generation of Suppressive Regulatory T Cells.

J. Fučíková, I. Truxová, M. Hensler, E. Becht, L. Kasíková, I. Moserová, S. Vošáhliková, J. Kloučková, S.E. Church, I. Cremer, O. Kepp, G. Kroemer, L. Galluzzi, C. Salek, R. Špíšek

Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.

I. Truxová, M. Hensler, P. Skapa, M. J. Halaska, J. Laco, A. Ryška, R. Špíšek, J. Fučíková.

Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents.

I. Moserová, I. Truxová, A.D. Garg, J. Tomala, P. Agostinis, P.F. Cartron, S. Vošáhlíková, M. Kovář, R. Špíšek, J. Fučíková

Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.

D. Myšíková, I. Adkins, N. Hradilová, O. Palata, J. Šimonek, J. Pozniak, J. Kolařík, A. Skallová-Fialová, R. Špíšek, R. Lischke

Case-Control Study: Smoking History Affects the Production of Tumor Antigen-Specific Antibodies NY-ESO-1 in Patients with Lung Cancer in Comparison with Cancer Disease-Free Group.

E. Vacchelli, N. Bloy, F. Aranda, A. Buqué, I. Cremer, S. Demaria, A. Eggermont, Ś.C. Formenti, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunotherapy plus radiation therapy for oncological indications.

K. Kloudová, H. Hromádková, S. Partlová, T. Brtnický, L. Rob, J. Bartůňková, M. Hensler, M.J. Halaška, R. Špíšek, A. Fialová

Expression of tumor antigens on primary ovarian cancer cells compared to established ovarian cancer cell lines.

A. Buqué, N. Bloy, F. Aranda, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L Galluzzi

Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy.

J. Fučíková, E. Becht, K. Iribarren, J. Goc, R. Remark, D. Damotte, M. Alifano, P. Devi, J. Biton, C. Germain, A. Lupo, W. H. Fridman, M. C. Dieu-Nosjean, G. Kroemer, C. Sautès-Fridman, I. Cremer

Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis.

S. Partlová, J. Bouček, K. Kloudová, M. Zábrodský, R. Špíšek, A. Fialová

Immune System in Patients with Head and Neck Carcinoma.

J. Fučíková, J. Bartůňková, R. Špíšek

The Concept of Immunogenic Cell Death in Antitumor Immunity

R. Mikyšková, I. Štěpánek, M. Indrová, J. Bieblová, J. Šímová, I. Truxová, I. Moserová, J. Fučíková, J. Bartůňková, R. Špíšek, M. Reiniš

Dendritic cells pulsed with tumor cells killed by high hydrostatic pressure induce strong immune responses and display therapeutic effects both in murine TC-1 and TRAMP-C2 tumors when combined with docetaxel chemotherapy.

M. Hensler, I. Vančurová, E. Becht, O. Palata, P. Strnad, P. Tesařová, M. Čabiňaková, D. Švec, M. Kubista, J. Bartůňková, R. Špíšek, L. Sojka

Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients.

J. Pol, A. Buqué, F. Aranda, N. Bloy, I. Cremer, A. Eggermont, P. Erbs, J. Fučíková, J. Galon, J. M. Limacher, X. Preville, C. Sautès-Fridman, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch-Oncolytic viruses and cancer therapy.

E. Vacchelli, F. Aranda, N. Bloy, A. Buqué, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch-Immunostimulation with cytokines in cancer therapy.

A. D. Garg, L. Galluzzi, L. Apetoh, T. Baert, R. B. Birge, J. M. Bravo-San Pedro, K. Breckpot, D. Brough, R. Chaurio, M. Cirone, A. Coosemans, P. G. Coulie, D. De Ruysscher, L. Dini, P. de Witte, A. M. Dudek-Peric, A. Faggioni, J. Fucikova, U.S. Gaipl, J. Golab, M. L. Gougeon, M. R. Hamblin, A. Hemminki, M. Herrmann, J.W. Hodge, O. Kepp, G. Kroemer, D. V. Krysko, W. G. Land, F. Madeo, A. A. Manfredi, S. R. Mattarollo, C. Maueroder, N. Merendino, G. Multhoff, T. Pabst, J.E. Ricci, C. Riganti, E. Romano, N. Rufo, M. J. Smyth, J. Sonnemann, R. Spisek, J. Stagg, E. Vacchelli, P. Vandenabeele, L. Vandenberk, B. J. Van den Eynde, S. Van Gool, F. Velotti, L. Zitvogel, P. Agostinis

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

K. Iribarren, N. Bloy, A. Buqué, I. Cremer, A. Eggermont, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy.

Jitka Fučíková, Irena Moserová, Linda Urbanová, Lucillia Bezu, Oliver Kepp, Isabelle Cremer, Cyril Salek, Pavel Strnad, Guido Kroemer, Lorenzo Galluzzi and Radek Špíšek

Prognostic and predictive value of DAMPs and DAMP-associated processes in cancer

J. Fučíková, I. Moserova, L. Urbanova,L. Bezu, O. Kepp, I. Cremer, C. Šálek, P. Strnad, G. Kroemer, L. Galluzzi, R. Špíšek

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

K. Dáňová, A. Klapetková, J. Kayserová, A. Šedivá, R. Špíšek, L.P. Jelínková

NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment.

M. Podrazil, R. Horváth, E. Becht, D. Rožková, P. Bílková, K. Sochorová, H. Hromádková, J. Kayserová, K. Vávrová, J. Laštovička, P. Vrabcová, K. Kubacková, Z. Gasová, L. Jarolim, M. Babjuk, R. Śpíšek, J. Bartůňková, J. Fučíková

Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer.

F. Aranda, A. Buqué, N. Bloy, F. Castoldi, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Adoptive cell transfer for oncological indications.

L. Bezu, L. C. Gomes-de-Silva, H. Dewitte, K. Breckpot, J. Fučíková, R. Špíšek, L. Galluzzi, O. Kepp, G. Kroemer

Combinatorial strategies for the induction of immunogenic cell death.

N. Bloy, A. Buqué, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, C. Sautès-Fridman, J. Fučiková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Naked and vectored DNA-based anticancer vaccines.

A. Buqué, N. Bloy, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, A. Marabelle, R. Špišek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications.

J. Pol, E. Vacchelli, F. Aranda, F. Castoldi, A. Eggermont, I. Cremer, C. Sautès-Fridman, J. Fučíková, J. Galon, R. Špíšek, E. Tartour, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy.

S. Partlová, J. Bouček, K. Kloudová, E Lukešová, M. Zábrodský, M. Grega, J. Fučíková, I. Truxová, R. Tachezy, R. Špíšek, A. Fialová

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma.

Irena Adkins, Jitka Fučíková, Abhishek D. Garg, Patrizia Agostinis, Radek Špíšek

Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy

N. Bloy, J. Pol, F. Aranda, A. Eggermont, I. Cremer, W.H. Fridman, J. Fučíková, J. Galon, E. Tartour, R. Spisek, M.V. Dhodapkar, L. Zitvogel, G. Kroemer, L. Galluzzi

Trial watch: Dendritic cell-based anticancer therapy.

L. Galluzzi, E. Vacchelli, J. Bravo-San Pedro, A. Buqué, L. Senovilla, E.E. Baracco, N. Bloy, F. Castoldi, J. Abastado, P. Agostinis, R.N. Apte, F. Aranda, M. Ayyoub, P. Beckhove, J. Blay, L. Bracci, A. Caignard, C. Castelli, F. Cavallo, E. Celis, V.Cerundolo, A. Clayton, M.P. Colombo, L. Coussens, M. V. Dhodapkar, A. M. Eggermont, D.T. Fearon, W. H. Fridman, J. Fučíková, D.I. Gabrilovich, J. Galon, A. Garg, F. Ghiringhelli, G. Giaccone, E. Gilboa, S. Gnjatic, A. Hoos, A. Hosmalin, D. Jäger, P. Kalinski, K. Kärre, O. Kepp, R. Kiessling, J. M. Kirkwood, E. Klein, A. Knuth, C. E. Lewis, R. Liblau, M. T. Lotze, E. Lugli, J. Mach, F. Mattei, D. Mavilio, I. Melero, C. J. Melief, E. A. Mittendorf, L. Moretta, A. Odunsi, H. Okada, A. K. Palucka, M. E. Peter, K. J. Pienta, A. Porgador, G. C. Prendergast, G. A. Rabinovich, N. P. Restifo, N. Rizvi, C. Sautès-Fridman, H. Schreiber, B. Seliger, H. Shiku, B. Silva-Santos, M. J. Smyth, D. E. Speiser, R. Spisek, P. K. Srivastava, J. E.Talmadge , E. Tartour, S. H. Van Der Burg , ´B. J. Van Den Eynde, H. Vile R, Wagner, J. S. Weber, T. L. Whiteside, J. D. Wolchok, L. Zitvogel, W. Zou, G. Kroemer

Classification of current anticancer immunotherapies.

T. Brtnický, A. Fialová, J. Laštovička, L. Rob, R. Špíšek

Clinical relevance of regulatory T cells monitoring in the peripheral blood of ovarian cancer patients.

O. Kepp, L. Senovilla, I. Vitale, E. Vacchelli, S. Adjemian, P. Agostinis, L. Apetoh, F. Aranda, V. Barnaba, N. Bloy, L. Bracci, K. Breckpot, D. Brough, A. Buqué, M.G. Castro, M. Cirone, M. I. Colombo, I. Cremer, S. Demaria, L. Dini, A. G. Eliopoulos, A. Faggioni, S.C. Formenti, J. Fučíková, L. Gabriele, U. S. Gaipl, J. Galon, A. Garg, F. Ghiringhelli, N. A. Giese, Z. S. Guo, A. Hemminki, M. Herrmann, J.W. Hodge, S. Holdenrieder, J. Honeychurch, H. M. Hu, X. Huang, T. M. Illidge, K. Kono, M. Korbelik, D. V. Krysko, S. Loi, P.R. Lowenstein, E. Lugli, Y. Ma, F. Madeo, A. A. Manfredi, I. Martins, D. Mavilio, L. Menger, N. Merendino, M. Michaud, G. Mignot, K. L. Mossman, G. Multhoff, R. Oehler, F. Palombo, T. Panaretakis, J. Pol, E. Proietti, J. E. Ricci, C. Rigant, P. Rovere-Querini, A. Rubartelli, A. Sistigu, M. J. Smyth, J. Sonnemann, R. Špišek, J. Stagg, A.Q. Sukkurwala, E. Tartour, A. Thorburn, S. H. Thorne, P. Vandenabeele, F. Velotti, S. T. Workenhe, H. Yang, W. X. Zong, L. Zitvogel, G. Kroemer, L. Galluzzi

Consensus guidelines for the detection of immunogenic cell death.

I. Adkins, J. Kamanova, A. Kocourkova, M. Svedova, J. Tomala, H. Janova, J. Masin, B. Chladkova, L. Bumba, M. Kovar, P.J. Ross, L. Tuckova, R. Spisek, K.H. Mills, P. Sebo

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.

I. Truxová, K. Pokorná, K. Kloudová, S. Partlová, R. Špíšek, J. Fučíková

Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.

J. Kayserová, J. Včeláková, K. Štechová, E. Dudková, H. Hromádková, Z. Sumnik, S. Koloušková, R. Špíšek, A. Šedivá

Decreased dendritic cell numbers but increased TLR9-mediated interferon-alpha production in first degree relatives of type 1 diabetes patients.

Iva Truxová, Kateřina Pokorná, Kamila Kloudová, Simona Partlová, Radek Špíšek, Jitka Fučíková

Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.

J. Fučíková, I.Moserová, I. Truxová, I. Heřmanová, I. Vančurová, S. Partlová, A. Fialová, L. Sojka, P.F. Cartron, M. Houska, L. Rob, J. Bartůňková, R. Špíšek

High hydrostatic pressure induces immunogenic cell death in human tumor cells.

Jitka Fučíková, Irena Moserová, Iva Truxová, Ivana Heřmanová, Irena Vančurová, Simona Partlová, Anna Fialová, Luděk Sojka, P.F. Cartron, M. Houska, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

High hydrostatic pressure induces immunogenic cell death in human tumor cells

I. Adkins, L. Sadilková, L. Palová-Jelínková

Bacterial toxins in cancer immunotherapy

Erika Vacchelli, Ilio Vitale, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fučíková, Isabelle Cremer, Jérôme Galon, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi

Trial watch: Dendritic cell-based interventions for cancer therapy.

Anna Fialová, Simona Partlová, Luděk Sojka, Hana Hromádková, Tomáš Brtnický, Jitka Fučíková, P. Kocian, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells.

Oliver Klein, Lisa M Ebert, Damien Zanker, Katherine Woods, Bee Shin Tan, Jitka Fučíková, Andreas Behren, Ian D. Davis, Eugene Maraskovsky, Weisan Chen, Jonathan Cebon

Flt3 ligand expands CD4+ FoxP3+ regulatory T cells in human subjects.

Ashley J. Knights, Jitka Fučíková, Anupama Pasam, Sandra Koernig, Jonathan Cebon

Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy.

Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková and Radek Špíšek

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials.

Petr Kocián, Monika Šedivcová, Jan Drgáč, Kateřina Černá, Jiří Hoch, Roman Kodet, Jiřina Bartůňková, Radek Špíšek, Anna Fialová

Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.

Rudolf Horváth, Daniela Rožková, Jan Lašt'ovička, Andrea Poloučková,Petr Sedláček, Anna Šedivá, Radek Špíšek

Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease.

Jitka Fučíková, Petra Králíkova, Anna Fialová, Tomáš Brtnický, Lukáš Rob, Jiřina Bartůňková,Radek Špíšek

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

Jitka Fučíková, Petra Králíková, Anna Fialová, Tomáš Brtnický, Lukáš Rob, Jiřina Bartůňková, Radek Špíšek

Human tumor cells killed by anthracyclines induce a tumor-specific immune response.

Daniela Rožková, Linda Novotná, Robert Pytlík, Ivana Hochová, Tomáš Kozák, Jiřina Bartůňková, Radek Špíšek

Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation.

Klára Sochorová, Vít Budinský, Daniela Rožková, Zuzana Tobiasová, Sylvie Dusilová-Sulková, Radek Špíšek, Jiřina Bartůňková

Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells.

A. Kučera, K. Pycha, P. Pajer, R. Špíšek, R. Škaba

Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination.

Daniela Rožková, Hana Tišerová, Jitka Fučíková, Jan Lašt'ovička, Michal Podrazil, Hana Ulčová, Vít Budínský, Jana Prausová, Zdeněk Linke, Ivo Minárik, Anna Šedivá, Radek Špíšeka, Jiřina Bartůňková et al.

FOCUS on FOCIS: combined chemo-immunotherapy for the treatment of hormone-refractory metastatic prostate cancer.

Sayuri Yamazaki, Anthony J. Bonito, Radek Špíšek, Madhav Dhodapkar, Kayo Inaba, Ralph M. Steinman

Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.

Radek Špíšek, Madhav V. Dhodapkar

Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells.

Radek Špíšek, Anna Charalambous, Amitabha Mazumder, David H. Vesole, Sundar Jagannath, Madhav V. Dhodapkar

Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications.

Radek Špíšek, Anjli Kukreja, Lin-Chi Chen, Phillip Matthews, Amitabha Mazumder, David Vesole, Sundar Jagannath, Henry A. Zebroski, Andrew J.G. Simpson, Gerd Ritter, Brian Durie, John Crowley et al.

Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy.

Klára Sochorová, Rudolf Horváth, Daniela Rožková, Jiří Litzman, Jiřina Bartůňková, Anna Šedivá, Radek Špíšek

Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.

Zuzana Tobiásová, Dagmar Pospíšilová, Ashley M. Miller, Ivo Minárik, Klára Sochorová, Radek Špíšek, Lukáš Rob, Jiřina Bartůňková

In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients.

Radek Špíšek

Immunoprevention of cancer: time to reconsider timing of vaccination against cancer.

Daniela Rožková, Rudolf Horváth, Jiřina Bartůňková, Radek Špíšek

Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors.

Radek Špíšek, Madhav V. Dhodapkar

Immunoprevention of cancer.

Radek Špíšek, Zdena Gašová, Jiřina Bartůňková

Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease.

Evžen Bouřa, D. Liebl, Radek Špíšek, Jan Frič, M. Marek, J. Stokrová, Vladimír Holán, Jitka Forstová

Polyomavirus EGFP-pseudocapsids: analysis of model particles for introduction of proteins and peptides into mammalian cells.

Lenka Palová-Jelínková, Daniela Rožková, Barbara Pecharová, Jiřina Bártová, Anna Šedivá, Helena Tlaskalová-Hogenová, Radek Špíšek, Ludmila Tučková

Gliadin fragments induce phenotypic and functional maturation of human dendritic cells.

Dagmar Pospíšilová, Jiřina Borovičková, Daniela Rožková, Jan Starý, Daniela Seifertová, Zuzana Tobiásová, Radek Špíšek, Jiřina Bartůňková

Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children. Med Oncol 2005;22: 79-88.

Radek Špíšek; Jitka Brazová; Daniela Rožková; Kateřina Zapletalová; Anna Šedivá; Jiřina Bartůňková

Maturation of dendritic cells by bacterial immunomodulators.

Radek Špíšek, Gwenola Bougras, Frederic Ebstein, Delphine Masse, Khaled Meflah, Dorian McIlroy, Marc Gregoire

Transient exposure of dendritic cells to maturation stimuli is sufficient to induce complete phenotypic maturation while preserving their capacity to respond to subsequent restimulation.

M. Grégoire, C. Ligeza-Poisson, N. Juge-Morineau, R. Špíšek

Anti-cancer therapy using dendritic cells and apoptotic tumour cells: pre-clinical data in human mesothelioma and acute myeloid leukaemia.

David Favre, Véronique Blouin, Nathalie Provost, Radek Špíšek, Françoise Porrot, Delphine Bohl, Frederic Marmé, Yan Chérel, Anna Salvetti, Bruno Hurtrel, Jean-Michel Heard, Yves Rivière, Philippe Moullier et al.

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.

Radek Špíšek, Patrice Chevallier, Nadine Morineau, Noël Milpied, Herve Avet-Loiseau, Jean-Luc Harousseau, Khaled Meflah, Marc Gregoire

Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin.

Dagmar Pospíšilová, Jiřina Borovičková, Andrea Poloučková, Radek Špíšek, Anna Šedivá, Ondřej Hrušák, Jan Starý, Jiřina Bartůňková

Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukemia.

Radek Špíšek, Laurent Bretaudeau, Isabelle Barbieux I, Khaled Meflah, Marc Gregoire

Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use.