Company Background:

SOTIO Biotech a. s. is a mid-sized biotech company developing novel protein-based anti-cancer therapies. The Biologics Core Technologies (BCT) team is at the heart of SOTIO research and development across multiple projects and drug modalities, which enables us to make a direct impact on drug candidate selection. We are responsible for molecular design and optimization of drug candidates to achieve the desired mode of action, for the supply of high-quality research material, and for characterization of our molecules to understand the relationship between structure and function. As a rapidly growing team, we are looking for new talents to
join us.

Position Summary:

We are looking for an individual to strengthen our protein characterization capabilities. In this role, you will collaborate with external partners on protein characterization experiments to elucidate structure of our molecules, conduct investigations and assess their suitability for further development (developability). You will review data, draw conclusions and present results in cross-functional meetings. You will also be expected to independently identify gaps in the knowledge around our molecules and propose activities/analyses to fill those gaps. This is primarily not a lab-based role, although you will closely collaborate with our analytical lab team.

Key Activities and Responsibilities:

  • Assume responsibility for assigned protein characterization experiments and studies (e.g. SPR and BLI testing, mass spectroscopy analysis, polyspecificity ELISA, epitope mapping and others – depending on candidate’s profile and technical expertise)
  • Collaborate with external contract research organizations on the design, contracting, execution and interpretation of experiments, provide scientific guidance
  • Present and discuss data in internal team meetings
  • Coordinate with other functions to make sure the proposed activities are relevant within the project context
  • Represent the BCT team in cross-functional project meetings
  • Carefully document executed experiments in detailed reports in the electronic lab book (in English language)
  • Actively drive technology and development benchmarking with industry (conferences, literature, patents)

Competences, Skills and Qualification:

  • Education in life sciences area (minimum Master’s degree), PhD. is a plus
  • 3+ years of hands-on experience with characterization of protein-based molecules in industry or academia setting (including PhD.) using at least some of the following methods: SPR, BLI, mass spectrometry, DSC or DSF, HIC, SEC or SEC-MALS, CD, FTIR or similar
  • Thorough knowledge of the structure and structure/function relationships of antibodies and/or antibody-drug conjugates
  • Good knowledge and previous hands-on experience with protein characterization using mass spectrometry is a plus
  • Good knowledge and previous hands-on experience with antibody discovery using display technologies or immunization is a plus
  • Proficient language skills in written and oral English (at least B2 level)
  • Solid skills in use of MS Office (Excel, Word, PowerPoint, Outlook)
  • Thoroughness, attention to detail
  • Proactive attitude, ability to work individually as well as in a team


Českomoravská 2532/19b, 190 00 Praha 9, Česká republika

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